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Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C

Medically attended RV-C-induced wheeze is characterised by a Th2 inflammatory pattern, independent of viral load

Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM-85

The effects of OM-85 were strongest in the first winter season, with a trend for fewer children in the OM-85 group to have sLRIs and URIs

Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children

The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children

Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations

Acute viral bronchiolitis in infants and young children

Anya Deborah Pat Jones Strickland Holt BSc MSc PhD PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary Research Associate Head, Pregnancy and Early Life

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained

Using Systems Biology to understand asthma exacerbations and develop better treatments

Alexander Anthony Deborah Emma Pat Larcombe Kicic Strickland de Jong Holt BScEnv (Hons) PhD BSc (Hons) PhD PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary

Working Towards a Better Understanding of ARF

Goal: Characterize the pattern of contemporary and endemic ARF and develop a biological signature to improve sensitivity and specificity of ARF diagnosis.

New funding for innovative multiple sclerosis research

WA researchers hope to gain new insights into the way immune cells in the body trigger attacks of multiple sclerosis (MS), thanks to new funding from MS Australia.

What is triggering immune reactions in people with MS?

Multiple sclerosis (MS) is a condition where a person's immune system attacks the brain and spinal cord.