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Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study

Continuous complete clinical remission in T-cell acute lymphoblastic leukemia (T-ALL) is now approaching 80% due to the implementation of aggressive...

Hemispheric division of function is the result of independent probabilistic biases

Causal theories propose that functional asymmetry is an obligatory pattern of organisation, while statistical theories maintain this is a reflection...

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven...

Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy

Topical application of tumors with the TLR7 agonist imiquimod is an effective adjunct treatment for a range of primary dermatological cancers.

Effects of simulated tidal and deep breathing on immature airway contraction to acetylcholine and nerve stimulation

In adults, respiratory movements, such as tidal and deep breaths, reduce airway smooth muscle force and cause bronchodilation.

The reliability of a food frequency questionnaire for use among adolescents

Accurate measurement of dietary intake is essential for understanding the long-term effects of adolescent diet on chronic disease risk.

Adolescent dietary patterns are associated with lifestyle and family psychosocial factors

Few studies have examined the dietary patterns of adolescents and the social and environmental factors that may affect them during this life stage.

Successful establishment of primary small airway cell cultures in human lung transplantation

The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway

Theories of otitis media pathogenesis, with a focus on Indigenous children

Otitis media is a common childhood illness associated with hearing loss, social disadvantage and medical costs. Prevalence and severity are high among...

Investigating genotype-phenotype relationships in Rett syndrome using an international data set

This study uses data from a large international database, InterRett, to examine genotype-phenotype relationships and compares these with previous findings in...