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Developing national guidelines for intervention with children on the autism spectrum in AustraliaInvestigators: Prof Andrew Whitehouse, Prof David Trembath Project description This project involves developing a national practice guideline for
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Research
Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian adolescents and young adultsVitamin D deficiency is a public health concern worldwide. Maintaining vitamin D sufficiency during growth periods is essential. We aimed to determine the prevalence and predictors of vitamin D deficiency in Australian adolescents and young adults.
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Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditionsAlthough genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk.
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Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humansThe proportion of 25(OH)D3 that undergoes epimerization is greater with oral vitamin D3 supplementation than exposure to UVR in mice, but not in humans
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Molecular actions of Vitamin D in reproductive cell biologyThe aim of this work is to review current metabolic and molecular aspects of the VitD-VitD receptor axis in reproductive medicine
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Vitamin D in fetal development: Findings from a birth cohort studyBirth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life.
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Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: The Raine studySun exposure is associated with several ophthalmic diseases, including pterygium which may develop in adolescence.
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Unpacking the complex nature of the autism epidemicThis paper discusses changes in diagnostic criteria, decreasing age at diagnosis, improved case ascertainment, diagnostic substitution, and social influences.
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Adult psychosocial outcomes of children with specific language impairment, pragmatic language impairment and autismEvidence that some children also develop autistic symptomatology over time has raised suggestions that developmental language disorder...
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A preliminary investigation of the effects of prenatal alcohol exposure on facial morphology in children with Autism Spectrum DisorderWhile early exposure to alcohol may influence the development of facial structures, it does not appear to be associated with ASD phenotypic variability
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Predicting outcome following mild traumatic brain injury: Protocol for the longitudinal, prospective, observational Concussion Recovery (CREST) cohort studyMild traumatic brain injury (mTBI) is a complex injury with heterogeneous physical, cognitive, emotional and functional outcomes. Many who sustain mTBI recover within 2 weeks of injury; however, approximately 10%-20% of individuals experience mTBI symptoms beyond this 'typical' recovery timeframe, known as persistent post-concussion symptoms (PPCS). Despite increasing interest in PPCS, uncertainty remains regarding its prevalence in community-based populations and the extent to which poor recovery may be identified using early predictive markers.
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Content validation of the Quality of Life Inventory—DisabilitySatisfactory content validity is reported, where ongoing consumer feedback shaped the dataset from which the final items were selected