Search
Research
In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in miceIn utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
Research
T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergyTo show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy.
Research
A genomics-based approach to assessment of vaccine safety and immunogenicity in childrenThis methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...
Research
Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell toleranceConcerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption...
Research
Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmaticsOur findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
Research
Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulatorThis study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal
Research
Respiratory viral infections and host responses; insights from genomicsReview of the viral sensing pathways and organizing principles that govern the innate immune response to infection
Research
Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways diseaseVitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
Research
Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjectsMononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells
Research
Rhinovirus-induced asthma exacerbations and risk populationsAsthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function