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Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic
Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare.
Fusionfinder: A software tool to identify expressed gene fusion candidates from RNA-seq data
The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions.
Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2
In T-cell acute lymphoblastic leukemia (T-ALL) cytogenetic alterations juxtapose the LIM-domain-only-2 gene (LMO2) with T-cell receptor loci.
Associate Professor Laurence Cheung
Co-Head, Leukaemia Translational Research
Professor Rishi S. Kotecha
Co-Head, Leukaemia Translational Research
Professor Ursula Kees
Honorary Emeritus Fellow
Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines
Glucocorticoids (GCs) are among the most important drugs for the treatment of acute lymphoblastic leukaemia (ALL).