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The ARC Centre of Excellence for Children and Families over the Life Course (Life Course Centre or LCC)The Life Course Centre is a national centre funded by the Australian Research Council Centre of Excellence Scheme and hosted through the University of Queensland with collaborating nodes at the University of Western Australia, Sydney University and University of Melbourne.


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Directing immune development to curb sky-rocketing diseaseOnce upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism.
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Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother–offspring cohort studiesPregnancy and birth cohorts have been utilised extensively to investigate the developmental origins of health and disease, particularly in relation to...

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The Life Course CentreThe Australian Research Council (ARC) Centre of Excellence for Children and Families Over the Life Course
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Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.This study identifies widespread DNA methylation changes in whole blood associated with childhood obesity.
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Relationship between the neighbourhood built environment and early child developmentThe relationship between features of the neighbourhood built environment and early child development was investigated
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Improvement in Psychosocial Outcomes in Children with Type 1 Diabetes and Their Parents Following Subsidy for Continuous Glucose MonitoringIntroduction of subsidized CGM showed early improvement in psychosocial and glycemic outcomes in patients and their families in Western Australia
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Distress and psychological morbidity do not reduce over time in carers of patients with high-grade gliomahis study aimed to determine how carer distress and psychological morbidity change over time following a patient's diagnosis of high-grade glioma
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The glycaemic benefits of a very-low-carbohydrate ketogenic diet in adults with Type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemiaThis study provides the first evidence that, ketogenic diets in adults with Type 1 diabetes are associated with excellent HbA1c levels and little glycaemic variability
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Impact of adolescent peer aggression on later educational and employment outcomes in an Australian cohortThis study used prospective birth cohort data to analyse the relationship between peer aggression at 14 years of age and educational and employment outcomes...
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The time lag prior to the rise in glucose requirements to maintain stable glycaemia during moderate exercise in a fasted insulinaemic state is of short durationThere is a 20-min low exogenous glucose demand period during which the glucose requirements to maintain stable glycaemia do not increase during moderate exercise
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Self-harm: Prevalence estimates from the second Australian Child and Adolescent Survey of Mental Health and WellbeingThe demonstrated higher risks in young people for continued harm or possible death support the need for ongoing initiatives to reduce self-harm
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ISPAD Clinical Practice Consensus Guidelines 2018: Exercise in children and adolescents with diabetesPromotion of regular physical activity is an integral part of diabetes care delivery and health care providers should promote this message at every available opportunity
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Introducing ‘Young Minds Matter’This article describes the survey, the response rates achieved and the representativeness of the sample for the Young Minds Matter survey
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Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: A randomised controlled trial protocolDetermine the effectiveness of 6 months' closed-loop compared with manually determined insulin dosing on time-in-target glucose range in adults with type 1 diabetes
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Disruptive mood dysregulation disorder in ICD-11: a new disorder or ODD with a specifier for chronic irritabilityThis letter congratulates Mulraney et al. regarding their paper on disruptive mood dysregulation disorder in children with ADHD.
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Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management SystemLonger suspends and fewer glycemic excursions occur at night compared with day
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Patterns of multiple risk exposures for low receptive vocabulary growth 4-8 years in the Longitudinal Study of Australian ChildrenOur results demonstrate a range of multiple risk profiles in a population-representative sample of Australian children and highlight the mix of risk factors faced by children